Therefore, the using a capsule with these
properties should be widely effectible to hide the islets form immune system. According
to studies, overexpression of the jagged-1 in cells (specially in tumor cells)
induces regulatory T cells. In this project we protected islets by conjugating
Jagged-1 on the microcapsule surface as a potent agent to induce regulatory T
cells around the graft to” hide” islet as same as tumors hide themselves from
immune attack.